Oas1b-dependent Immune Transcriptional Profiles of West Nile Virus Infection in the Collaborative Cross

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Oas1b-dependent Immune Transcriptional Profiles of West Nile Virus Infection in the Collaborative Cross

The oligoadenylate-synthetase (Oas) gene locus provides innate immune resistance to virus infection. In mouse models, variation in the Oas1b gene influences host susceptibility to flavivirus infection. However, the impact of Oas variation on overall innate immune programming and global gene expression among tissues and in different genetic backgrounds has not been defined. We examined how Oas1b...

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West Nile virus (WNV) is an emerging mosquito-borne flavivirus that causes annual epidemics of encephalitic disease throughout the world. Despite the ongoing risk to public health, no approved vaccines or therapies exist for use in humans to prevent or combat WNV infection. The innate immune response is critical for controlling WNV replication, limiting virus-induced pathology, and programming ...

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1. Centers for Disease Control and Prevention. Poliomyelitis—Madagascar 2002. MMWR Morb Mortal Wkly Rep 2002;51:622. 2. Guillot S, Caro V, Cuervo N, Korotkova E, Combiescu M, Persu A, et al.] Natural genetic exchanges between vaccine and wild poliovirus strains in humans. J Virol 2000;74:8434–43. 3. Pringle CR. Virus taxonomy at the XIth International Congress of Virology, Sydney, Australia, 19...

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ژورنال

عنوان ژورنال: G3 Genes|Genomes|Genetics

سال: 2017

ISSN: 2160-1836

DOI: 10.1534/g3.117.041624